Genome-wide variants and polygenic risk scores for cognitive impairment following blood or marrow transplantation.

ABSTRACT: Cognitive impairment is prevalent in blood or marrow transplantation (BMT) recipients, albeit with inter-individual variability. We conducted a genome-wide association study of objective cognitive function assessed longitudinally in 239 adult BMT recipients for discovery and replicated in an independent cohort of 540 BMT survivors. Weighted genome-wide polygenic risk scores (PRS) were constructed using linkage disequilibrium pruned significant SNPs. Forty-four genome-wide significant SNPs were identified using additive (n = 3); codominant (n = 20) and genotype models (n = 21). Each additional copy of a risk allele was associated with a 0.28-point (p = 1.07 × 10^-8) to a 1.82-point (p = 6.7 × 10^-12) increase in a global deficit score. We replicated two SNPs (rs11634183

SUBMITTER: Sharafeldin N 

PROVIDER: S-EPMC9233077 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature