A revised electronic version of RUCAM for the diagnosis of DILI.

ABSTRACT:

Background and aims

Roussel Uclaf Causality Assessment Method (RUCAM) for DILI has been hindered by subjectivity and poor reliability. We sought to improve the RUCAM using data from the Drug-Induced Liver Injury Network (DILIN) and the Spanish DILI Registry, published literature, and iterative computer modeling.

Approach and results

RUCAM criteria were updated, clarified, and computerized. We removed criteria 3 (risk factors) for lack of added value and criteria 4 because we felt it more useful to assess each drug separately. Criteria 6 (drug-specific risk) was anchored to LiverTox likelihood scores. Iterative testing in subsets of 50-100 single-agent, nonherbal cases from both registries was done to optimize performance. We used classification tree analysis to establish dia

SUBMITTER: Hayashi PH 

PROVIDER: S-EPMC9233102 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature