Gestational and childhood phthalate exposures and adolescent body composition: The HOME study.

ABSTRACT:

Background

Early life phthalate exposures may disrupt metabolism but results from human studies are inconsistent and few have examined body composition during adolescence. We investigated associations of gestational and childhood urinary phthalate biomarker concentrations with body composition at age 12 years.

Methods

We used data from 206 mother-child pairs in a prospective pregnancy and birth cohort enrolled in Cincinnati, OH from 2003 to 2006. We measured nine phthalate metabolites in spot urine samples collected twice from mothers during pregnancy and up to seven times from children at 1, 2, 3, 4, 5, 8, and 12 years. At age 12 years, we assessed fat and lean mass of the whole body and android and gynoid subregions, and visceral fat area with dual x-ray absorptiometry, an

SUBMITTER: Etzel TM 

PROVIDER: S-EPMC9233110 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature