Accuracy and Reproducibility of Myocardial Blood Flow Quantification by Single Photon Emission Computed Tomography Imaging in Patients With Known or Suspected Coronary Artery Disease.

ABSTRACT:

Background

Single photon emission computed tomography (SPECT) has limited ability to identify multivessel and microvascular coronary artery disease. Gamma cameras with cadmium zinc telluride detectors allow the quantification of absolute myocardial blood flow (MBF) and myocardial flow reserve (MFR). However, evidence of its accuracy is limited, and of its reproducibility is lacking. We aimed to validate ^99mTc-sestamibi SPECT MBF and MFR using standard and spline-fitted reconstruction algorithms compared with ¹³N-ammonia positron emission tomography in a cohort of patients with known or suspected coronary artery disease and to evaluate the reproducibility of this technique.

Methods

Accuracy was assessed in 34 participants who underwent dynamic ^99m</

SUBMITTER: de Souza ACDAH 

PROVIDER: S-EPMC9233115 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature