Association of the MACROD2 rs6110695 A>G polymorphism with an increasing WBC count in a Korean population.

ABSTRACT:

Introduction

We aimed to find a novel candidate gene related to the white blood cell (WBC) count in a Korean population. Since WBC count has been reported to have a relation to the risk of chronic diseases according to previous literature, WBC level prediction can be helpful for managing future risk of chronic disease development. In this aspect, a gene newly found in the present study is expected to be utilized as a tool for judging an individual's WBC level.

Methods

Based on the 153 study participants' genotype data produced by the Korean Chip. The mono-adenosine diphosphate ribosylhydrolase 2 (MACROD2) rs6110695 A>G polymorphism had a significant strong association with WBC count, thus, the MACROD2 gene emerged as a novel candidate gene for WBC count. To verify the effect

SUBMITTER: Yang J 

PROVIDER: S-EPMC9233196 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature