Controllable graphene oxide-based biocompatible hybrid interface as an anti-fibrotic coating for metallic implants.

ABSTRACT: In tissue engineering, foreign body reactions (FBRs) that may occur after the insertion of medical implants are a considerable challenge. Materials currently used in implants are mainly metals that are non-organic, and the lack of biocompatibility and absence of immune regulations may lead to fibrosis after long periods of implantation. Here, we introduce a highly biocompatible hybrid interface of graphene oxide (GO) and collagen type I (COL-I), where the topological nanostructure can effectively inhibit the differentiation of fibroblasts into myofibroblasts. The structure and roughness of this coating interface can be easily adjusted at the nanoscale level through changes in the GO concentration, thereby effectively inducing the polarization of macrophages to the M1 state without producin

SUBMITTER: Chen CY 

PROVIDER: S-EPMC9233272 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature