Revealing the recent demographic history of Europe via haplotype sharing in the UK Biobank.

ABSTRACT: Haplotype-based analyses have recently been leveraged to interrogate the fine-scale structure in specific geographic regions, notably in Europe, although an equivalent haplotype-based understanding across the whole of Europe with these tools is lacking. Furthermore, study of identity-by-descent (IBD) sharing in a large sample of haplotypes across Europe would allow a direct comparison between different demographic histories of different regions. The UK Biobank (UKBB) is a population-scale dataset of genotype and phenotype data collected from the United Kingdom, with established sampling of worldwide ancestries. The exact content of these non-UK ancestries is largely uncharacterized, where study could highlight valuable intracontinental ancestry references with deep phenotyping within the U

SUBMITTER: Gilbert E 

PROVIDER: S-EPMC9233301 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature