Model-based driving mechanism analysis for butyric acid production in Clostridium tyrobutyricum.

ABSTRACT:

Background

Butyric acid, an essential C4 platform chemical, is widely used in food, pharmaceutical, and animal feed industries. Clostridium tyrobutyricum is the most promising microorganism for industrial bio-butyrate production. However, the metabolic driving mechanism for butyrate synthesis was still not profoundly studied.

Results

This study reports a first-generation genome-scale model (GEM) for C. tyrobutyricum, which provides a comprehensive and systematic analysis for the butyrate synthesis driving mechanisms. Based on the analysis in silico, an energy conversion system, which couples the proton efflux with butyryl-CoA transformation by two redox loops of ferredoxin, could be the main driving force for butyrate synthesis. For verifying the driving mechanism, a hydroge

SUBMITTER: Feng J 

PROVIDER: S-EPMC9233315 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature