Longitudinal alterations of the gut mycobiota and microbiota on COVID-19 severity.

ABSTRACT:

Background

The impact of SARS-CoV-2 infection on the gut fungal (mycobiota) and bacterial (microbiota) communities has been elucidated individually. This study analyzed both gut mycobiota and microbiota and their correlation in the COVID-19 patients with severe and mild conditions and follow-up to monitor their alterations after recovery.

Methods

We analyzed the gut mycobiota and microbiota by bacterial 16S and fungal ITS1 metagenomic sequencing of 40 severe patients, 38 mild patients, and 30 healthy individuals and reanalyzed those of 10 patients with severe COVID-19 approximately 6 months after discharge.

Results

The mycobiota of the severe and mild groups showed lower diversity than the healthy group, and in some, characteristic patterns dominated by a single funga

SUBMITTER: Maeda Y 

PROVIDER: S-EPMC9233337 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature