Prognostic importance of systemic inflammation and insulin resistance in patients with cancer: a prospective multicenter study.

ABSTRACT:

Background

Systemic inflammation and insulin resistance (IR) are often associated with poor prognosis in cancer. This study aimed to investigate the prognostic value of surrogate systemic inflammation and IR indices in patients with cancer.

Methods

This multicenter prospective study included 5,221 patients with cancer, with a mean age of 59.41±11.15 years, of whom 3,061 (58.6%) were male. The surrogate IR indices included low-density lipoprotein cholesterol to high-density lipoprotein cholesterol (LHR) ratio, total cholesterol to high-density lipoprotein cholesterol (TC/ HDL-c) ratio, triglyceride to high-density lipoprotein cholesterol (TG/HDL-c) ratio, and fasting triglyceride glucose (TyG). Prognostic receiver operator characteristic (ROC) curves and C-indices were used t

SUBMITTER: Ruan GT 

PROVIDER: S-EPMC9233357 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature