DNA methylation changes in response to neoadjuvant chemotherapy are associated with breast cancer survival.

ABSTRACT:

Background

Locally advanced breast cancer is a heterogeneous disease with respect to response to neoadjuvant chemotherapy (NACT) and survival. It is currently not possible to accurately predict who will benefit from the specific types of NACT. DNA methylation is an epigenetic mechanism known to play an important role in regulating gene expression and may serve as a biomarker for treatment response and survival. We investigated the potential role of DNA methylation as a prognostic marker for long-term survival (> 5 years) after NACT in breast cancer.

Methods

DNA methylation profiles of pre-treatment (n = 55) and post-treatment (n = 75) biopsies from 83 women with locally advanced breast cancer were investigated using the Illumina HumanMethylation450 BeadChip. The patients rec

SUBMITTER: Pedersen CA 

PROVIDER: S-EPMC9233373 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature