Tradeoffs in milk immunity affect infant infectious disease risk.

ABSTRACT:

Background and objectives

The human immune system has evolved to balance protection against infection with control of immune-mediated damage and tolerance of commensal microbes. Such tradeoffs between protection and harm almost certainly extend to the immune system of milk.

Methodology

Among breastfeeding mother-infant dyads in Kilimanjaro, Tanzania, we characterized in vitro proinflammatory milk immune responses to Salmonella enterica (an infectious agent) and Escherichia coli (a benign target) as the increase in interleukin-6 after 24 h of incubation with each bacterium. We characterized incident infectious diseases among infants through passive monitoring. We used Cox proportional hazards models to describe associations between milk immune activity an

SUBMITTER: Wander K 

PROVIDER: S-EPMC9233416 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature