Neural processes related to negative self-concept in adult and adolescent anorexia nervosa.

ABSTRACT:

Objective

Negative self-concept is characteristic of anorexia nervosa (AN), but the neural processes mediating this component of AN is unknown. These studies investigated how valence and social perspectives impact neural processing in both adults and adolescents with AN.

Method

In an fMRI task, participants evaluated positive and negative adjectives from three social perspectives. Two studies were completed, one in 59 women (healthy, with AN, recovered from AN) and one in 42 adolescents (healthy, with AN). Neural regions of interest (ROIs) related to valence were identified and activations compared across groups and social perspectives.

Results

Behaviourally, both adult and adolescent cohorts with AN were less positive during self-evaluations. In the adult study, neur

SUBMITTER: Mendoza CJ 

PROVIDER: S-EPMC9233497 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature