Clearing the air: Uniquely engaging furin as an approach to cystic fibrosis therapy.

ABSTRACT: In this issue of Cell Chemical Biology, Douglas et al. describe a potent, specific, and cell-permeable furin inhibitor that interacts with a cryptic binding site to rescue hallmarks of cystic fibrosis in human ex vivo models. BOS-318 holds promise for development of therapeutics targeting an array of furin-dependent pathologies.

SUBMITTER: Nayak D 

PROVIDER: S-EPMC9233500 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature