Clearing the air: Uniquely engaging furin as an approach to cystic fibrosis therapy.
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ABSTRACT:
SUBMITTER: Nayak D
PROVIDER: S-EPMC9233500 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Publications
Clearing the air: Uniquely engaging furin as an approach to cystic fibrosis therapy.
Nayak Digant D Wasmuth Elizabeth V EV Olsen Shaun K SK
Cell chemical biology 20220601 6
In this issue of Cell Chemical Biology, Douglas et al. describe a potent, specific, and cell-permeable furin inhibitor that interacts with a cryptic binding site to rescue hallmarks of cystic fibrosis in human ex vivo models. BOS-318 holds promise for development of therapeutics targeting an array of furin-dependent pathologies. ...[more]
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