Sulfonamide Synthesis via Calcium Triflimide Activation of Sulfonyl Fluorides.

ABSTRACT: A method using calcium triflimide [Ca(NTf₂)₂] as a Lewis acid to activate sulfonyl fluorides toward nucleophilic addition with amines is described. The reaction converts a wide array of sterically and electronically diverse sulfonyl fluorides and amines into the corresponding sulfonamides in good yield.

SUBMITTER: Mukherjee P 

PROVIDER: S-EPMC9233624 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature