The Origins and Functions of De Novo Genes: Against All Odds?

ABSTRACT: "De novo" genes evolve from previously non-genic DNA. This strikes many of us as remarkable, because it seems extraordinarily unlikely that random sequence would produce a functional gene. How is this possible? In this two-part review, I first summarize what is known about the origins and molecular functions of the small number of de novo genes for which such information is available. I then speculate on what these examples may tell us about how de novo genes manage to emerge despite what seem like enormous opposing odds.

SUBMITTER: Weisman CM 

PROVIDER: S-EPMC9233646 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature