Cortical changes in patients with schizophrenia across two ethnic backgrounds.

ABSTRACT: While it is known that cultural background influences the healthy brain, less is known about how it affects cortical changes in schizophrenia. Here, we tested whether schizophrenia differentially affected the brain in Japanese and German patients. In a sample of 155 patients with a diagnosis of schizophrenia and 191 healthy controls from Japan and Germany, we acquired 3 T-MRI of the brain. We subsequently compared cortical thickness and cortical surface area to identify whether differences between healthy controls and patients might be influenced by ethnicity. Additional analyses were performed to account for effects of duration of illness and medication. We found pronounced interactions between schizophrenia and cultural background in the cortical thickness of several areas, including the

SUBMITTER: Langenbach BP 

PROVIDER: S-EPMC9233668 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature