Mucin induces CRISPR-Cas defense in an opportunistic pathogen.
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ABSTRACT:
SUBMITTER: de Freitas Almeida GM
PROVIDER: S-EPMC9233685 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Publications
Mucin induces CRISPR-Cas defense in an opportunistic pathogen.
de Freitas Almeida Gabriel Magno GM Hoikkala Ville V Ravantti Janne J Rantanen Noora N Sundberg Lotta-Riina LR
Nature communications 20220625 1
Parasitism by bacteriophages has led to the evolution of a variety of defense mechanisms in their host bacteria. However, it is unclear what factors lead to specific defenses being deployed upon phage infection. To explore this question, we co-evolved the bacterial fish pathogen Flavobacterium columnare and its virulent phage V156 in presence and absence of a eukaryotic host signal (mucin) for sixteen weeks. The presence of mucin leads to a dramatic increase in CRISPR spacer acquisition, especia ...[more]
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