Ontology highlight
ABSTRACT:
SUBMITTER: Vanli N
PROVIDER: S-EPMC9233706 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Vanli Nil N Sheng Jinghao J Li Shuping S Xu Zhengping Z Hu Guo-Fu GF
Communications biology 20220625 1
Prostate specific antigen screening has resulted in a decrease in prostate cancer-related deaths. However, it also has led to over-treatment affecting the quality of life of many patients. New biomarkers are needed to distinguish prostate cancer from benign prostate hyperplasia (BPH) and to predict aggressiveness of the disease. Here, we report that ribonuclease 4 (RNASE4) serves as such a biomarker as well as a therapeutic target. RNASE4 protein level in the plasma is elevated in prostate cance ...[more]