Sulfur regulation of the sulfate transporter genes sutA and sutB in Penicillium chrysogenum.

ABSTRACT: Penicillium chrysogenum uses sulfate as a source of sulfur for the biosynthesis of penicillin. Sulfate uptake and the mRNA levels of the sulfate transporter-encoding sutB and sutA genes are all reduced by high sulfate concentrations and are elevated by sulfate starvation. In a high-penicillin-yielding strain, sutB is effectively transcribed even in the presence of excess sulfate. This deregulation may facilitate the efficient incorporation of sulfur into cysteine and penicillin.

SUBMITTER: van de Kamp M 

PROVIDER: S-EPMC92338 | biostudies-literature | 2000 Oct

REPOSITORIES: biostudies-literature