Identification of Cigarette Smoking-Related Novel Biomarkers in Lung Adenocarcinoma.

ABSTRACT:

Objective

The aims of this study were to screen the gene mutations that are able to predict the risk of cigarette smoking-related lung adenocarcinoma (LUAD) and to evaluate its prognostic significance.

Methods

Clinical data and genetic information were retrieved from the TCGA database, and the patients with LUAD were divided into three groups including never smoking, light smoking, and heavy smoking according to cigarette smoking dose. Differentially mutated genes (DMGs) of each group were analyzed. At the same time, the function of DMGs in three smoking groups was evaluated by GO function and KEGG pathway analysis. The driver genes and protein variation effect of DMGs were performed to further screen key genes. The survival characteristics of the gene expression and mutatio

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9234045 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature