Genomic epidemiology of Salmonella Typhi in Central Division, Fiji, 2012 to 2016.

ABSTRACT:

Background

Typhoid fever is endemic in some Pacific Island Countries including Fiji and Samoa yet genomic surveillance is not routine in such settings. Previous studies suggested imports of the global H58 clade of Salmonella enterica var Typhi (Salmonella Typhi) contribute to disease in these countries which, given the MDR potential of H58, does not auger well for treatment. The objective of the study was to define the genomic epidemiology of Salmonella Typhi in Fiji.

Methods

Genomic sequencing approaches were implemented to study the distribution of 255 Salmonella Typhi isolates from the Central Division of Fiji. We augmented epidemiological surveillance and Bayesian phylogenomic approaches with a multi-year typhoid case-control study to define g

SUBMITTER: Davies MR 

PROVIDER: S-EPMC9234096 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature