Meta-Analysis of Down Syndrome Cortical Development Reveals Underdeveloped State of the Science.

ABSTRACT: Neurodevelopmental impairment contributes to the hallmark cognitive disability in individuals with Down syndrome (DS, trisomy 21, T21). The appearance of cognitive deficits in infancy suggests that alterations emerge during the earliest stages of neural development and continue throughout the lifespan in DS. Neural correlates of intellectual and language function include cortical structures, specifically temporal and frontal lobes that are smaller in DS. Yet, despite increased understanding of the DS cognitive-behavioral phenotype in childhood, there is very little structural and histological information to help explain the deficits. Consequently, attempts to effectively design therapeutic targets or interventions are limited. We present a systematic review of published research on cortica

SUBMITTER: Risgaard KA 

PROVIDER: S-EPMC9234119 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature