Central NPFF signalling is critical in the regulation of glucose homeostasis.

ABSTRACT:

Objective

Neuropeptide FF (NPFF) group peptides belong to the evolutionary conserved RF-amide peptide family. While they have been assigned a role as pain modulators, their roles in other aspects of physiology have received much less attention. NPFF peptides and their receptor NPFFR2 have strong and localized expression within the dorsal vagal complex that has emerged as the key centre for regulating glucose homeostasis. Therefore, we investigated the role of the NPFF system in the control of glucose metabolism and the histochemical and molecular identities of NPFF and NPFFR2 neurons.

Methods

We examined glucose metabolism in Npff^-/- and wild type (WT) mice using intraperitoneal (i.p.) glucose tolerance and insulin tolerance tests. Body composition and glucose tol

SUBMITTER: Zhang L 

PROVIDER: S-EPMC9234230 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature