White matter fiber-specific degeneration in older adults with metabolic syndrome.

ABSTRACT:

Objective

Metabolic syndrome (MetS) is defined as a complex of interrelated risk factors for type 2 diabetes and cardiovascular disease, including glucose intolerance, abdominal obesity, hypertension, and dyslipidemia. Studies using diffusion tensor imaging (DTI) have reported white matter (WM) microstructural abnormalities in MetS. However, interpretation of DTI metrics is limited primarily due to the challenges of modeling complex WM structures. The present study used fixel-based analysis (FBA) to assess the effect of MetS on the fiber tract-specific WM microstructure in older adults and its relationship with MetS-related measurements and cognitive and locomotor functions to better understand the pathophysiology of MetS.

Methods

Fixel-based metrics, including microstructur

SUBMITTER: Andica C 

PROVIDER: S-EPMC9234232 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature