Determination of tissue contributions to the circulating lipid pool in cold exposure via systematic assessment of lipid profiles.

ABSTRACT: Plasma lipid levels are altered in chronic conditions such as type 2 diabetes and cardiovascular disease as well as during acute stresses such as fasting and cold exposure. Advances in MS-based lipidomics have uncovered a complex plasma lipidome of more than 500 lipids that serve functional roles, including as energy substrates and signaling molecules. This plasma lipid pool is maintained through regulation of tissue production, secretion, and uptake. A major challenge in understanding the lipidome complexity is establishing the tissues of origin and uptake for various plasma lipids, which is valuable for determining lipid functions. Using cold exposure as an acute stress, we performed global lipidomics on plasma and in nine tissues that may contribute to the circulating lipid pool. We fou

SUBMITTER: Jain R 

PROVIDER: S-EPMC9234243 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature