Hypoxia in relationship to tumor volume using hypoxia PET-imaging in head & neck cancer - A scoping review.

ABSTRACT:

Background

Hypoxia and large tumor volumes are negative prognostic factors for patients with head and neck squamous cell carcinoma (HNSCC) treated with radiation therapy (RT). PET-scanning with specific hypoxia-tracers (hypoxia-PET) can be used to non-invasively assess hypoxic tumor volume. Primary tumor volume is readily available for patients undergoing RT. However, the relationship between hypoxic volume and primary tumor volume is yet an open question. The current study investigates the hypotheses that larger tumors contain both a larger hypoxic volume and a higher hypoxic fraction.

Methods

PubMed and Embase were systematically searched to identify articles fulfilling the predefined criteria. Individual tumor data (primary tumor volume and hypoxic volume/fraction) was ex

SUBMITTER: Hildingsson S 

PROVIDER: S-EPMC9234341 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature