Serum biomarkers for arterial calcification in humans: A systematic review.

ABSTRACT:

Aim

To clarify the role of mediators of ectopic mineralization as biomarkers for arterial calcifications.

Methods

MEDLINE and Embase were searched for relevant literature, until January 4th 2022. The investigated biomarkers were: calcium, phosphate, parathyroid hormone, vitamin D, pyrophosphate, osteoprotegerin, receptor activator of nuclear factor-kappa B ligand (RANKL), fibroblast growth factor-23 (FGF-23), Klotho, osteopontin, osteocalcin, Matrix Gla protein (MGP) and its inactive forms and vitamin K. Studies solely performed in patients with kidney insufficiency or diabetes mellitus were excluded.

Results

After screening of 8985 articles, a total of 129 articles were included in this systematic review. For all biomarkers included in this review, the results were v

SUBMITTER: Goluke NMS 

PROVIDER: S-EPMC9234354 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature