Genome-Wide Association Study for Chronic Hepatitis B Infection in the Thai Population.

ABSTRACT: To identify novel host genetic variants that predispose to hepatitis B virus (HBV) persistence, we performed the first genome-wide association study in the Thai population involving 318 cases of chronic hepatitis B and 309 healthy controls after quality control measures. We detected the genome-wide significant association of the HLA class II region (HLA-DPA1/DPB1, rs7770370, p-value = 7.71 × 10^-10, OR = 0.49) with HBV chronicity. Subsequent HLA allele imputation revealed HLA-DPA1*01:03 (Pc = 1.21 × 10^-6, OR = 0.53), HLA-DPB1*02:01 (Pc = 2.17 × 10^-3, OR = 0.50), and HLA-DQB1*06:09 (Pc = 2.17 × 10^-2, OR = 0.07) as protective alleles, and HLA-DPA1*02:02 (Pc = 6.32 ×

SUBMITTER: Ashouri S 

PROVIDER: S-EPMC9234442 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature