Modelling the tumor immune microenvironment for precision immunotherapy.

ABSTRACT: The complexity of the cellular and acellular players within the tumor microenvironment (TME) allows for significant variation in TME constitution and role in anticancer treatment response. Spatial alterations in populations of tumor cells and adjacent non-malignant cells, including endothelial cells, fibroblasts and tissue-infiltrating immune cells, often have a major role in determining disease progression and treatment response in cancer. Many current standard systemic antineoplastic treatments target the cancer cells and could be further refined to directly target commonly dysregulated cell populations of the TME. Recent developments in immuno-oncology and bioengineering have created an attractive potential to model these complexities at the level of the individual patient. These develo

SUBMITTER: Mackenzie NJ 

PROVIDER: S-EPMC9234475 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature