Development of a Robotic Shear Wave Elastography System for Noninvasive Staging of Liver Disease in Murine Models.

ABSTRACT: Shear wave elastography (SWE) is an ultrasound-based stiffness quantification technology that is used for noninvasive liver fibrosis assessment. However, despite widescale clinical adoption, SWE is largely unused by preclinical researchers and drug developers for studies of liver disease progression in small animal models due to significant experimental, technical, and reproducibility challenges. Therefore, the aim of this work was to develop a tool designed specifically for assessing liver stiffness and echogenicity in small animals to better enable longitudinal preclinical studies. A high-frequency linear array transducer (12-24 MHz) was integrated into a robotic small animal ultrasound system (Vega; SonoVol, Inc., Durham, NC) to perform liver stiffness and echogenicity measurements in t

SUBMITTER: Czernuszewicz TJ 

PROVIDER: S-EPMC9234684 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature