Imaging the stability of chronic electrical microstimulation using electrodes coated with PEDOT/CNT and iridium oxide.

ABSTRACT: Chronic microstimulation is faced with challenges that require an additional understanding of stability and safety. We implanted silicon arrays coated with poly(3,4-ethylenedioxythiophene) (PEDOT)/Carbon Nanotubes (CNT), or PCand IrOx into the cortex of GCaMP6s mice and electrically stimulated them for up to 12 weeks. We quantified neuronal responses to stimulation using two-photon imaging and mesoscale fluorescence microscopy and characterized electrode performance over time. We observed dynamic changes in stimulation stability over time and a significant advantage in energy efficiency using PC coated electrodes over IrOx coated electrodes. In a subset of mice, we observed abnormal ictal cortical responses or cortical spreading depression using stimulation parameters commonly used in intr

SUBMITTER: Zheng XS 

PROVIDER: S-EPMC9234710 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature