Protein interaction networks in neurodegenerative diseases: From physiological function to aggregation.

ABSTRACT: The accumulation of protein inclusions is linked to many neurodegenerative diseases that typically develop in older individuals, due to a combination of genetic and environmental factors. In rare familial neurodegenerative disorders, genes encoding for aggregation-prone proteins are often mutated. While the underlying mechanism leading to these diseases still remains to be fully elucidated, efforts in the past 20 years revealed a vast network of protein-protein interactions that play a major role in regulating the aggregation of key proteins associated with neurodegeneration. Misfolded proteins that can oligomerize and form insoluble aggregates associate with molecular chaperones and other elements of the proteolytic machineries that are the frontline workers attempting to protect the cell

SUBMITTER: Calabrese G 

PROVIDER: S-EPMC9234719 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature