Type-2 cGMP-dependent protein kinase suppresses proliferation and carcinogenesis in the colon epithelium.

ABSTRACT: A large body of evidence has demonstrated that cyclic-guanosine monophosphate (cGMP), signaling has anti-tumor effects that might be used for colon cancer prevention. The tumor-suppressive mechanism and the signaling components downstream of cGMP remain largely unknown. The present study has characterized the expression of cGMP-dependent protein kinases (PKG1, PKG2) in normal and cancerous tissue from human colon. PKG1 was detected in both normal and tumor tissue, where it localized exclusively to the lamina propria and stroma (respectively). In contrast, PKG2 localized specifically to the epithelium where its expression decreased markedly in tumors compared to matched normal tissue. Neither PKG isoform was detected at the RNA or protein level in established colon cancer cell lines. To tes

SUBMITTER: Islam BN 

PROVIDER: S-EPMC9234760 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature