Sex Differences in Airway Remodeling and Inflammation: Clinical and Biological Factors.

ABSTRACT: Asthma is characterized by an increase in the contraction and inflammation of airway muscles, resulting in airflow obstruction. The prevalence of asthma is lower in females than in males until the start of puberty, and higher in adult women than men. This sex disparity and switch at the onset of puberty has been an object of debate among many researchers. Hence, in this review, we have summarized these observations to pinpoint areas needing more research work and to provide better sex-specific diagnosis and management of asthma. While some researchers have attributed it to the anatomical and physiological differences in the male and female respiratory systems, the influences of hormonal interplay after puberty have also been stressed. Other hormones such as leptin have been linked to the s

SUBMITTER: Ekpruke CD 

PROVIDER: S-EPMC9234861 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature