Low Levels Matter: Clinical Relevance of Low Pru p 3 sIgE in Patients With Peach Allergy.

ABSTRACT: Many clinical lab settings still use 0.35 KU_A/L as the cut-off for serum specific-IgE (sIgE) immunoassays, while the detection limit is 0.1 KU_A/L. The clinical relevance of -low-level sIgE (0.1-0.35 KU_A/L) remains controversial. Pru p 3 sIgE is considered to be the main routine tool for assessing lipid transfer protein (LTP) sensitization. We aimed to evaluate the clinical relevance of Pru p 3 sIgE low levels in a population diagnosed with LTP allergy. Adults diagnosed with LTP allergy and Pru p 3 sIgE ≥ 0.1 KUA/L between 2012 and 2019 were included. Clinical data were reviewed. nPru p 3 basophil activation test (BAT) was performed and basophil reactivity (BR) and sensitivity (BS) correlated with the peach allergy symptoms. Pru p 3 sIgE from 496 subjects wa

SUBMITTER: Balsells-Vives S 

PROVIDER: S-EPMC9234939 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature