A Human-derived Dual MRI/PET Reporter Gene System with High Translational Potential for Cell Tracking.

ABSTRACT:

Purpose

Reporter gene imaging has been extensively used to longitudinally report on whole-body distribution and viability of transplanted engineered cells. Multi-modal cell tracking can provide complementary information on cell fate. Typical multi-modal reporter gene systems often combine clinical and preclinical modalities. A multi-modal reporter gene system for magnetic resonance imaging (MRI) and positron emission tomography (PET), two clinical modalities, would be advantageous by combining the sensitivity of PET with the high-resolution morphology and non-ionizing nature of MRI.

Procedures

We developed and evaluated a dual MRI/PET reporter gene system composed of two human-derived reporter genes that utilize clinical reporter probes for engineered cell detection. As a pr

SUBMITTER: Shalaby N 

PROVIDER: S-EPMC9235057 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature