Expression of fatty acid synthase genes and their role in development and arboviral infection of Aedes aegypti.

ABSTRACT:

Background

Fatty acids are the building blocks of complex lipids essential for living organisms. In mosquitoes, fatty acids are involved in cell membrane production, energy conservation and expenditure, innate immunity, development and reproduction. Fatty acids are synthesized by a multifunctional enzyme complex called fatty acid synthase (FAS). Several paralogues of FAS were found in the Aedes aegypti mosquito. However, the molecular characteristics and expression of some of these paralogues have not been investigated.

Methods

Genome assemblies of Ae. aegypti were analyzed, and orthologues of human FAS was identified. Phylogenetic analysis and in silico molecular characterization were performed to identify the functional domains of the Ae. aegypti FAS (AaFAS). Quantitative

SUBMITTER: Chotiwan N 

PROVIDER: S-EPMC9235097 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature