In vitro photodynamic therapy of methylene blue-loaded acetyl resistant starch nanoparticles.

ABSTRACT:

Background

Combination therapies comprising multiple methods, such as photodynamic therapy have been applied to be complements chemotherapy as they increase the therapeutic efficiency by enabling the intelligent drug delivery to target sites by exposing the photosensitizer to light and activating it in the tumor tissue. This study evaluated in vitro photodynamic therapy of methylene blue (MB)-loaded acetyl resistant starch (ARS) nanoparticles (NPs).

Methods

ARS was synthesized by the reaction between resistant starch (RS) and acetic anhydride. MB-loaded ARS NPs and ARS NPs were prepared by a single emulsion method. Synthesized ARS was measured by NMR. Prepared ARS NPs and MB-loaded ARS NPs were characterized by transmission electron microscopy (TEM), dynamic light scattering

SUBMITTER: Park IK 

PROVIDER: S-EPMC9235160 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature