Impact of linkage disequilibrium heterogeneity along the genome on genomic prediction and heritability estimation.

ABSTRACT:

Background

Compared to medium-density single nucleotide polymorphism (SNP) data, high-density SNP data contain abundant genetic variants and provide more information for the genetic evaluation of livestock, but it has been shown that they do not confer any advantage for genomic prediction and heritability estimation. One possible reason is the uneven distribution of the linkage disequilibrium (LD) along the genome, i.e., LD heterogeneity among regions. The aim of this study was to effectively use genome-wide SNP data for genomic prediction and heritability estimation by using models that control LD heterogeneity among regions.

Methods

The LD-adjusted kinship (LDAK) and LD-stratified multicomponent (LDS) models were used to control LD heterogeneity among regions and were comp

SUBMITTER: Ren D 

PROVIDER: S-EPMC9235212 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature