Role of exosomes in the pathogenesis, diagnosis, and treatment of central nervous system diseases.

ABSTRACT: Central nervous system (CNS) diseases, such as multiple sclerosis, Alzheimer's disease (AD), and Parkinson's disease (PD), affect millions of people around the world. Great efforts were put in disease related research, but few breakthroughs have been made in the diagnostic and therapeutic approaches. Exosomes are cell-derived extracellular vesicles containing diverse biologically active molecules secreted by their cell of origin. These contents, including nucleic acids, proteins, lipids, amino acids, and metabolites, can be transferred between different cells, tissues, or organs, regulating various intercellular cross-organ communications and normal and pathogenic processes. Considering that cellular environment and cell state strongly impact the content and uptake efficiency of exosomes,

SUBMITTER: Fan Y 

PROVIDER: S-EPMC9235237 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature