Interleukin-6 and YKL-40 predicted recurrent stroke after ischemic stroke or TIA: analysis of 6 inflammation biomarkers in a prospective cohort study.

ABSTRACT:

Objective

Contribution of individual and combined inflammatory markers in prognosis after stroke was still undefined. We aimed to investigate the association of systemic and local vascular inflammatory markers and recurrent stroke as well as impact on poor functional outcome.

Methods

In this pre-specified substudy of the Third China National Stroke Registry (CNSR-III), 10,472 consecutive acute ischemic stroke or TIA patients with available centralized-measured levels of Interleukin-6 (IL-6), high sensitive C-reactive protein (hsCRP), IL-1 receptor antagonist (IL-1Ra), lipoprotein-associated phospholipase A₂ mass (Lp-PLA₂) and activity (Lp-PLA₂-A), and YKL-40 from 171 sites were enrolled. The primary outcomes consisted of stroke recurrence and

SUBMITTER: Li J 

PROVIDER: S-EPMC9235241 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature