Transcranial doppler as screening method for sickling crises in children with sickle cell anemia: a latin America cohort study.

ABSTRACT:

Background

Sickle cell anemia (SCA) is the leading cause of childhood stroke. We aimed to evaluate whether altered cerebral flow velocities, as measured by transcranial Doppler (TCD), are associated with vaso-occlusive complications in addition to stroke in pediatric SCA patients.

Methods

We evaluated 37 children aged between 2 and 16 years with SCA who underwent screening for TCD between January 2012 and October 2018. Genotypic profiles and demographic data were collected, TCD examinations were performed during follow-up, and the presence of sickling crises was compared. Survival analyses were performed using simple frailty models, in which each predictor variable was analyzed separately in relation to the occurrence of a sickling crisis.

Results

The variables relate

SUBMITTER: Modolo GP 

PROVIDER: S-EPMC9235247 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature