A tale of two transmitters: serotonin and histamine as in vivo biomarkers of chronic stress in mice.

ABSTRACT:

Background

Stress-induced mental illnesses (mediated by neuroinflammation) pose one of the world's most urgent public health challenges. A reliable in vivo chemical biomarker of stress would significantly improve the clinical communities' diagnostic and therapeutic approaches to illnesses, such as depression.

Methods

Male and female C57BL/6J mice underwent a chronic stress paradigm. We paired innovative in vivo serotonin and histamine voltammetric measurement technologies, behavioral testing, and cutting-edge mathematical methods to correlate chemistry to stress and behavior.

Results

Inflammation-induced increases in hypothalamic histamine were co-measured with decreased in vivo extracellular hippocampal serotonin in mice that underwent a chronic stress paradigm, rega

SUBMITTER: Hersey M 

PROVIDER: S-EPMC9235270 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature