The host micro-RNA cfa-miR-346 is induced in canine leishmaniasis.

ABSTRACT:

Background

Leishmaniases are a group of anthropo-zoonotic parasitic diseases caused by a protozoan of the Leishmania genus, affecting both humans and other vertebrates, including dogs. L. infantum is responsible for the visceral and occasionally cutaneous form of the disease in humans and canine leishmaniasis. Previously, we have shown that L. infantum induces a mild but significant increase in endoplasmic reticulum (ER) stress expression markers to promote parasites survival in human and murine infected macrophages. Moreover, we demonstrated that the miRNA hsa-miR-346, induced by the UPR-activated transcription factor sXBP1, was significantly upregulated in human macrophages infected with different L. infantum strains. However, the ER stress response in infected dogs, which repres

SUBMITTER: Buffi G 

PROVIDER: S-EPMC9235276 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature