Lidocaine Ineffectiveness Suggests New Psychopharmacology Drug Target.

ABSTRACT:

Objectives

The mechanism of many neuropsychiatric disorders remains unknown, but the ineffectiveness of the sodium channel blocker lidocaine has been suggested to be a biomarker for Attention Deficit Hyperactivity Disorder (ADHD) and a severe form of Premenstrual Syndrome (PMS) that is considered psychiatric. We conducted single-arm double-blind clinical trials to test whether lidocaine ineffectiveness can be used as a biomarker to identify people with these conditions and provide a clue as to the molecular mechanism and potential psychopharmacological intervention.

Experimental design

We developed a noninvasive taste test for lidocaine ineffectiveness, validated by comparing lidocaine injections to pain testing in 12 subjects, and assessed it in individuals with ADHD and PM

SUBMITTER: Mintz M 

PROVIDER: S-EPMC9235314 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature