Loss of Hilnc prevents diet-induced hepatic steatosis through binding of IGF2BP2.

ABSTRACT: The Hedgehog (Hh) signalling pathway plays a critical role in regulating liver lipid metabolism and related diseases. However, the underlying mechanisms are poorly understood. Here, we show that the Hh signalling pathway induces a previously undefined long non-coding RNA (Hilnc, Hedgehog signalling-induced long non-coding RNA), which controls hepatic lipid metabolism. Mutation of the Gli-binding sites in the Hilnc promoter region (Hilnc^BM/BM) decreases the expression of Hilnc in vitro and in vivo. Hilnc^BM/BM and Hilnc-knockout mice are resistant to diet-induced obesity and hepatic steatosis through attenuation of the peroxisome proliferator-activated receptor signalling pathway, as Hilnc directly interacts with IGF2BP2 to enhance Pparγ mRNA stability. Furthermore, we

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC9235319 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature