Differential Contribution of NF-κB Signaling Pathways to CD4⁺ Memory T Cell Induced Activation of Endothelial Cells.

ABSTRACT: Endothelial cells (ECs) are important contributors to inflammation in immune-mediated inflammatory diseases (IMIDs). In this study, we examined whether CD4⁺ memory T (T_m) cells can drive EC inflammatory responses. Human T_m cells produced ligands that induced inflammatory responses in human umbilical vein EC as exemplified by increased expression of inflammatory mediators including chemokines and adhesion molecules. NF-κB, a key regulator of EC activation, was induced by T_m cell ligands. We dissected the relative contribution of canonical and non-canonical NF-κB signaling to T_m induced EC responses using pharmacological small molecule inhibitors of IKKβ (iIKKβ) or NF-κB inducing kinase (iNIK). RNA sequencing revealed substantial overlap

SUBMITTER: Jeucken KCM 

PROVIDER: S-EPMC9235360 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature