Impact of delayed graft function on clinical outcomes in highly sensitized patients after deceased-donor kidney transplantation.

ABSTRACT:

Background

We investigated whether the development of delayed graft function (DGF) in pre-sensitized patients affects the clinical outcomes after deceased-donor kidney transplantation (DDKT).

Methods

The study included 709 kidney transplant recipients (KTRs) from three transplant centers. We divided KTRs into four subgroups (highly sensitized DGF, highly sensitized non-DGF, low-sensitized DGF, and low-sensitized non-DGF) according to panel reactive antibody level of 50%, or DGF development. We compared post-transplant clinical outcomes among the four subgroups.

Results

Incidence of biopsy-proven acute rejection (BPAR) was higher in two highly sensitized subgroups than in low-sensitized subgroups. It tended to be higher in highly sensitized DGF subgroups than in the hi

SUBMITTER: Kim SG 

PROVIDER: S-EPMC9235446 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature