Plasma CXCL14 as a Candidate Biomarker for the Diagnosis of Lung Cancer.

ABSTRACT:

Background

Effective biomarkers for early diagnosis of lung cancer are needed. Previous studies have indicated positive associations between abnormal circulating cytokines and the etiology of lung cancer.

Methods

Blood samples were obtained from 286 patients with pretreatment lung cancer and 80 healthy volunteers. Circulating cytokine levels were detected with a Luminex assay and enzyme-linked immunosorbent assay (ELISA). Urine samples were obtained from 284 patients and 122 healthy volunteers. CXC chemokine ligand 14 (CXCL14) expression in tumors and nontumor regions of lung tissues from 133 lung cancer cases was detected by immunohistochemical (IHC) staining and immunofluorescence (IF) staining of formalin fixed paraffin-embedded (FFPE) tissues.

Results

Compared wit

SUBMITTER: Tian PF 

PROVIDER: S-EPMC9235466 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature